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PeakForce QNM Atomic Force Microscopy Imaging Mode

Unprecedented Quantitative Characterization of Nanoscale Materials

Living Glioblastoma Cells by PeakForce QNM and the BioScope Catalyst Atomic Force Microscope

PeakForce QNM® (Quantitative Nanomechanical Property Mapping) Atomic Force Microscopy Imaging Mode allows quantitative nanomechanical mapping of material properties, including modulus and adhesion, while simultaneously imaging sample topography at high resolution. Based on Bruker's exclusive Peak Force Tapping™ technology, the PeakForce QNM imaging mode records very fast force response curves at every single pixel in the image. Thus, the forces applied to the sample are precisely controlled and a variety of probes can be used. It also allows measurement of material properties over an extremely wide range: ~1 MPa to 50 GPa for modulus and 10 pN to 10 μN for adhesion, encompassing many sample types. These capabilities dramatically exceed those of any other technique for nanoscale materials characterization and will change the way you think about and use atomic force microscopy.

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See brochures, application notes, and other links related to the PeakForce QNM imaging mode

Features of the PeakForce QNM Atomic Force Microsopy Imaging Mode

• Longer probe lifetimes, fewer probe exchanges, and improved sample integrity and measurement consistency
• Obtain maps of sample modulus and adhesion, along with high-resolution topography images with little or no extra effort
• Peak Force Tapping precisely controls imaging force to keep indentations small, enabling non-destructive and high-resolution imaging
• Widest operating range for samples from soft gels (~1 MPa) to rigid polymers (>20 GPa)

AFM Imaging Live Biological Samples

The promising PeakForce QNM imaging mode and Peak Force Tapping technique applied by the BioScope™ Catalyst™ AFM look to provide the acquisition speed and quality resolution needed to measure the mechanical properties of living cells ex vivo — thereby surpassing the previous limitations of force spectroscopy. Our exciting life sciences application note gives an overview of the biological samples that can be imaged and the unique information that can be extracted from the atomic force microscopy data.

Quantitative Imaging of Living Biological Samples by PeakForce QNM Atomic Force Microscopy (Application Note, PDF)

Associated Atomic Force Microscopes

BioScope Catalyst Atomic Force Microscope

Dimension FastScan Atomic Force Microscope

Dimension Icon Atomic Force Microscope

MultiMode 8 Atomic Force Microscope

Brochure and Application Notes

PeakForce QNM: Quantitative Nanomechanical Property Mapping (Brochure, PDF)

Quantitative Imaging of Living Biological Samples by PeakForce QNM Atomic Force Microscopy (Application Note, PDF)

BioScope Catalyst: Accessing All Biological Size Scales with High-Resolution Atomic Force Microscopy Imaging (Application Note, PDF)

Common Approaches to Tip Functionalization for AFM-Based Molecular Recognition (Application Note, PDF)

Introduction to ScanAsyst Imaging Mode and Peak Force Tapping Atomic Force Microscopy Technology (Application Note, PDF)

Articles

New Atomic Force Microscopy (AFM) Approaches Life Sciences Gently, Quantitatively, and Correlatively (April 2012 – American Laboratory)

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